FITC标记的异常凝血酶原/脱-γ-羧基凝血酶原抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的异常凝血酶原/脱-γ-羧基凝血酶原抗体

FITC标记的异常凝血酶原/脱-γ-羧基凝血酶原抗体

商家询价

产品名称： FITC标记的异常凝血酶原/脱-γ-羧基凝血酶原抗体

英文名称： Anti-DCP/FITC

产品编号： HZ-1037R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： Flow-Cyt=1:50-200 IF=1:50-200

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 Rabbit Anti-DCP/FITC Conjugated antibody

 

FITC标记的异常凝血酶原/脱-γ-羧基凝血酶原抗体
英文名称 Anti-DCP/FITC
中文名称 FITC标记的异常凝血酶原/脱-γ-羧基凝血酶原抗体
别    名 Des-gamma-carboxy (abnormal)prothrombin; Des-Gamma-carboxy-prothrombin.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 肿瘤  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, 
产品应用 Flow-Cyt=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DCP
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Des-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. Normally, the prothrombin precursor undergoes post-translational carboxylation (addition of a carboxylic acid group) by gamma-glutamyl carboxylase in the liver prior to secretion into plasma. DCP/PIVKA-II may be detected in people with deficiency of vitamin K (due to poor nutrition or malabsorption) and in those taking warfarin or other medication that inhibits the action of vitamin K.

Function:
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.

Subunit:
Heterodimer (named alpha-thrombin) of a light and a heavy chain; disulfide-linked. Forms a heterodimer with SERPINA5.

Subcellular Location:
Secreted, extracellular space.

Tissue Specificity:
Expressed by the liver and secreted in plasma.

Post-translational modifications:
The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin. 
N-glycosylated. N-glycan heterogeneity at Asn-121: Hex3HexNAc3 (minor), Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). At Asn-143: Hex4HexNAc3 (minor) and Hex5HexNAc4 (major). 
Factor II deficiency (FA2D) [MIM:613679]: A very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. Note=The disease is caused by mutations affecting the gene represented in this entry. 
Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note=Disease susceptibility is associated with variations affecting the gene represented in this 
Thrombophilia due to thrombin defect (THPH1) [MIM:188050]: A multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. Note=The disease is caused by mutations affecting the gene represented in this entry. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. 
Pregnancy loss, recurrent, 2 (RPRGL2) [MIM:614390]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Similarity:
Belongs to the peptidase S1 family. 
Contains 1 Gla (gamma-carboxy-glutamate) domain. 
Contains 2 kringle domains. 
Contains 1 peptidase S1 domain.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

正常肝细胞中，在内质网内可将DCP羧化使之成为有活性的凝血酶原，一旦机体需要，凝血酶原即可转变成凝血酶参与机体的各项生理功能，当有肿瘤细胞发生时，DCP明显升高。DCP主要用于肝癌方面的研究；有学者认为：联合应用DCP和AFP对于早期诊断HCC（原发性肝细胞癌）有较大的帮助。
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   

 

carboxyprothrombin DES -γ（DCP），也被称为维生素K缺乏诱导蛋白拮抗剂Ⅱ号（PIVKA-Ⅱ型），是一种异常的凝血蛋白，prothrombin。通常情况下，前体的prothrombin undergoes转动后carboxylation（加法）的羧基酶γ-谷氨酰）由肝脏分泌进入到在现有的等离子体。DCP /凝血酶原前体可以被检测到的人的维生素K（与不足或吸收不良导致的营养不良）的患者与那些接受药物治疗，或其他的抑制作用维生素K的动作