FITC标记的磷酸化DNA甲基转移酶-3α抗体
产品名称： FITC标记的磷酸化DNA甲基转移酶-3α抗体
英文名称： Anti-phospho-Dnmt3a(Ser390 + Ser393)/FITC
产品编号： HZ-14399R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-phospho-Dnmt3a(Ser390 + Ser393)/FITC Conjugated antibody
FITC标记的磷酸化DNA甲基转移酶-3α抗体
| 英文名称 | Anti-phospho-Dnmt3a(Ser390 + Ser393)/FITC |
| 中文名称 | FITC标记的磷酸化DNA甲基转移酶-3α抗体 |
| 别 名 | Dnmt3a (phospho S390 + S393); p-Dnmt3a (phospho S390 + S393); DNA (cytosine 5) methyltransferase 3 alpha; DNA (cytosine 5) methyltransferase 3A; DNA (cytosine-5)-methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase 3a; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; DNM3A_HUMAN; DNMT 3a; DNMT; Dnmt3a; DNMT3A2; M.HsaIIIA; MCMT; OTTHUMP00000201149. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 102kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from human Dnmt3a around the phosphorylation site of（Ser390 + Ser393） |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] Function: Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity. Subcellular Location: Nucleus. Cytoplasm. Accumulates in the major satellite repeats at pericentric heterochromatin. Tissue Specificity: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. Post-translational modifications: Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription. Similarity: Belongs to the C5-methyltransferase family. Contains 1 ADD domain. Contains 1 GATA-type zinc finger. Contains 1 PHD-type zinc finger. Contains 1 PWWP domain. Database links: Entrez Gene: 1788 Human Entrez Gene: 359716 Cow Entrez Gene: 482996 Dog Entrez Gene: 444984 Rat Omim: 602769 Human SwissProt: Q9Y6K1 Human SwissProt: Q1LZ53 Rat Unigene: 515840 Human Unigene: 92659 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CpG甲基化是胚胎发育、印迹和X染色体失活的重要表观遗传修饰。在小鼠中的研究已经表明，DNA甲基化是哺乳动物发育所必需的。这个基因编码一种DNA甲基转移酶，被认为在甲基化转变中起作用，而不是维持甲基化。蛋白质定位于细胞质和细胞核，其表达受到发育调控。多重TRAN中的选择性剪接结果