FITC标记的肌动蛋白抑制因子1抗体
产品名称： FITC标记的肌动蛋白抑制因子1抗体
英文名称： Anti-SACM1L/FITC
产品编号： HZ-19362R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-SACM1L/FITC Conjugated antibody
FITC标记的肌动蛋白抑制因子1抗体
| 英文名称 | Anti-SACM1L/FITC |
| 中文名称 | FITC标记的肌动蛋白抑制因子1抗体 |
| 别 名 | Phosphatidylinositide phosphatase SAC1; SAC1; SAC1 suppressor of actin mutations 1-like (yeast); SAC1_HUMAN; SACM1L; suppressor of actin 1; Suppressor of actin mutations 1-like protein. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 信号转导 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, Sheep, Cat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 67kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SACM1L |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Saccharomyces cerevisiae SAC1 gene modulates yeast actin function and alleviates the essential requirement for phosphatidylinositol transfer protein (sec14p) activity in Golgi secretory function. The SAC1 gene product (Sac1p) is an integral membrane lipid phosphatase of the endoplasmic reticulum (ER) and the Golgi complex and contains a Sac phosphatase domain (1-2). Sac1p functions in a wide range of cellular processes including inositol metabolism, actin cytoskeletal organization, endoplasmic reticulum ATP transport, phosphatidylinositol-phospha-tidylcholine transfer protein function and multiple-drug sensitivity (3). Sac1p is an important regulator of microsomal ATP transport, providing a link between inositol phospholipid signaling and ATP-dependent processes in the yeast ER (4). Defects in Sac1p relieves the requirement for Sec14p by altering phospholipid metabolism to expand the pool of diacylglycerol in the Golgi (5). Sac1p dysfunction exerts its pleiotropic effects on yeast Golgi function, the organization of the actin cytoskeleton, and the cellular requirement for inositol, through altered metabolism of inositol glycerophospholipids (6). These effects suggest the secretory and cytoskeletal activities are coordinated to achieve proper spatial regulation of secretion in S. cerevisiae (7). Function: Phosphoinositide phosphatase that hydrolyzes PtdIns(3)P and PtdIns(4)P. Has low activity towards PtdIns(3,5)P2. Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Detected in heart, brain, lung, liver, kidney, pancreas and testis. Similarity: Contains 1 SAC domain. Database links: Entrez Gene: 530577 Cow Entrez Gene: 484795 Dog Entrez Gene: 101787561 Guinea pig Entrez Gene: 100065601 Horse Entrez Gene: 22908 Human Entrez Gene: 83493 Mouse Entrez Gene: 116482 Rat Entrez Gene: 791142 Zebrafish Omim: 606569 Human SwissProt: A6QL88 Cow SwissProt: Q9NTJ5 Human SwissProt: Q9EP69 Mouse SwissProt: Q9ES21 Rat SwissProt: A1L244 Zebrafish Unigene: 156509 Human Unigene: 273671 Mouse Unigene: 161978 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
酿酒酵母SAC1基因调节酵母肌动蛋白功能，缓解高尔基体分泌功能对磷脂酰肌醇转移蛋白（sec14p）活性的基本要求。SAC1基因产物(Sac1p)是内质网(ER)和高尔基复合物的整体膜脂磷酸酶，并含有Sac磷酸酶结构域(1-2)。Sac1p在广泛的细胞过程中起作用，包括肌醇代谢、肌动蛋白细胞骨架组织、内质网ATP转运、磷脂酰肌醇-磷脂-替胆碱转运蛋白功能和多药敏感性(3)。Sac1p是微粒体ATP转运的重要调节因子，在酵母ER(4)中肌醇磷脂信号转导和ATP依赖性过程之间提供了联系。Sac1p的缺陷通过改变磷脂代谢来扩大高尔基体中的二酰甘油池，从而缓解了对Sec14p的需求。Sac1p功能障碍通过改变肌醇甘油磷脂的代谢，对酵母的高尔基体功能、肌动蛋白细胞骨架的组织和细胞对肌醇的需求发挥其多效作用(6)。这些效果表明，分泌和细胞骨架活动协调，以实现适当的。