FITC标记的异质核糖核蛋白H抗体
产品名称： FITC标记的异质核糖核蛋白H抗体
英文名称： Anti-hnRNP H/FITC
产品编号： HZ-17333R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-hnRNP H/FITC Conjugated antibody
FITC标记的异质核糖核蛋白H抗体
| 英文名称 | Anti-hnRNP H/FITC |
| 中文名称 | FITC标记的异质核糖核蛋白H抗体 |
| 别 名 | DKFZp686A15170; Heterogeneous nuclear ribonucleoprotein H; Heterogeneous nuclear ribonucleoprotein H1 (H); Heterogeneous nuclear ribonucleoprotein H1; HNRH1_HUMAN; hnRNP H; hnRNPH; hnRNPH1; HNRPH 1; HNRPH; HNRPH1 protein; N-terminally processed. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Zebrafish, Rhesus monkey, Gorilla, Opossum, Orangutan, Elephant |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human hnRNP H |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012] Function: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). Subunit: Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent. Subcellular Location: Nucleus; nucleoplasm. Tissue Specificity: Expressed ubiquitously. Similarity: Contains 3 RRM (RNA recognition motif) domains. Database links: Entrez Gene: 3187 Human Entrez Gene: 59013 Mouse Entrez Gene: 140931 Rat Omim: 601035 Human SwissProt: P31943 Human SwissProt: O35737 Mouse SwissProt: Q8VHV7 Rat Unigene: 604001 Human Unigene: 21740 Mouse Unigene: 23677 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码一个亚家族成员的普遍表达的异质性核核糖核蛋白（HNRNPs）。HNRNPS是与异质核RNA复合的RNA结合蛋白。这些蛋白与核内的前mRNA相关联，并似乎影响前mRNA处理和mRNA代谢和转运的其他方面。虽然所有的HNRNPs存在于细胞核中，有的可能在细胞核和细胞质之间穿梭。HNRNP蛋白具有不同的核酸结合特性。该基因编码的蛋白具有三个与RNA结合的准RRM结构域，与HNRPF家族成员非常相似。这个基因可能与遗传性淋巴水肿I型相关。已经描述了另一种剪接的转录体变体[由RefSeq，2012年3月提供]。