FITC标记的分选连接蛋白5抗体-抗体-抗体-生物在线
上海沪震实业有限公司
FITC标记的分选连接蛋白5抗体

FITC标记的分选连接蛋白5抗体

商家询价

产品名称： FITC标记的分选连接蛋白5抗体

英文名称： Anti-SNX5/FITC

产品编号： HZ-12248R-FITC

产品价格： null

产品产地： 中国/上海

品牌商标： HZbscience

更新时间： 2023-08-17T10:24:20

使用范围： ICC=1:50-200 IF=1:50-200

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 Rabbit Anti-SNX5/FITC Conjugated antibody 

FITC标记的分选连接蛋白5抗体

 

英文名称 Anti-SNX5/FITC
中文名称 FITC标记的分选连接蛋白5抗体
别    名 0910001N05Rik; 1810032P22Rik; AU019504; D2Ertd52e; FLJ10931; OTTHUMP00000030340; OTTHUMP00000062927; OTTMUSP00000003367; OTTMUSP00000003368; RP11-504H3.2; RP23-35E16.2; snoRNA MBI-43; SNX 5; SNX5; SNX5_HUMAN; Sorting nexin 5; Sorting nexin-5.  
规格价格 100ul/2980元 购买        大包装/询价
说 明 书 100ul  
研究领域 细胞生物  信号转导  生长因子和激素  转录调节因子  激酶和磷酸酶  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 ICC=1:50-200 IF=1:50-200  
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
细胞定位 细胞膜 
性    状 Lyophilized or Liquid
浓    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from Human SNX5 (2-75aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
产品介绍 background:
Sorting nexin 1 (SNX1) is a member of a large family of hydrophilic proteins that interact with a variety of receptor types and are involved in intracellular trafficking (1). SNX1 and the related splice variant, SNX1A, bind the epidermal growth factor (EGF) receptor, facilitate its transport to lysosome, and thereby contribute to the degradation of the receptor (2,3). SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain (4). These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases (2). These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes (1,5). The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors (2,6).

Function:
May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation.

Subunit:
Interacts with SNX1; this promotes location at the endosome membrane. 

Subcellular Location:
Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3,4-bisphosphate (PdtIns(3,4)P2). Detected on macropinosomes. Targeted to membrane ruffles in response to EGFR stimulation. 

Similarity:
Belongs to the sorting nexin family.
Contains 1 BAR domain.
Contains 1 PX (phox homology) domain.

Database links:
UniProtKB/Swiss-Prot: Q9Y5X3.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
   

排序Nexin 1（SNX1）是一大家族的亲水性蛋白质，其与多种受体类型相互作用，并参与细胞内运输（1）。SNX1和相关剪接变异体SNX1A结合表皮生长因子（EGF）受体，促进其向溶酶体的转运，从而有助于受体（2,3）的降解。SNX2和SNX4与SNX1具有高度的氨基酸相似性，因为它们都含有特征PHX同源性（Px）结构域（4）。这些蛋白都与细胞膜部分相关，并且它们同样与EGF、PDGF和胰岛素受体酪氨酸激酶(2)相关。这些NEXIN广泛表达，但具有多种组织分布模式。此外，分选连接蛋白可以彼此结合并与多种其他细胞蛋白结合，表明它们作为多亚基复合物（1，5）的一部分存在。相关蛋白SNX3包括连接蛋白的不同亚群，其在PX结构域外具有较少的序列相似性，并且对酪氨酸激酶受体(2，6)具有显著不同的结合亲和力。