FITC标记的胰腺癌转移相关蛋白RLLM1抗体
产品名称： FITC标记的胰腺癌转移相关蛋白RLLM1抗体
英文名称： Anti-RLLM1/FITC
产品编号： HZ-6514R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-RLLM1/FITC Conjugated antibody
FITC标记的胰腺癌转移相关蛋白RLLM1抗体
| 英文名称 | Anti-RLLM1/FITC |
| 中文名称 | FITC标记的胰腺癌转移相关蛋白RLLM1抗体 |
| 别 名 | CGI 99; CGI99; CLE; Homeobox prox 1; RLLM1; Chromosome 14 open reading frame 166; CLE7; LCRP369; RLL motif containing 1; CN166_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 染色质和核信号 神经生物学 信号转导 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 28kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human RLLM1/C14orf166 (188-230aa) |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈. |
| 产品介绍 | background: CGI-99 is a 244 amino acid protein that localizes to the nucleus, as well as to the cytoplasm, and belongs to the UPF0568 family. Expressed in a variety of tissues with particularly high levels in heart and skeletal muscle, CGI-99 functions as a homodimer that interacts with Ninein and is thought to regulate Ninein function. CGI-99 is overexpressed in brain tumor tissue, suggesting a role in tumor development and metastasis. The gene encoding CGI-99 maps to human chromosome 14, which houses over 700 genes and comprises nearly 3.5% of the human genome. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease (AD). The SERPINA1 gene is also located on chromosome 14 and, when defective, leads to the genetic disorder ?-antitrypsin deficiency, which is characterized by severe lung complications and liver dysfunction. Function: The function of the C14orf266 gene has not yet been determined, but it is widely expressed, at high levels in heart and skeletal muscle and at intermediate levels in liver, pancreas, foetal brain and foetal lung. It is weakly expressed in adult brain, adult lung, placenta, foetal liver and foetal kidney, and overexpressed in many brain tumors.Cellular localization;Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. centrosome.May localize at the centrosome during mitosis. Subunit: Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex. Interacts with influenza A virus RNA polymerase subunits PA, PB1 and PB2, and nucleocapsid NP. Interacts with hepatitis C virus core protein p19. Subcellular Location: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, centrosome. Note=May localize at the centrosome during mitosis. Tissue Specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors. Similarity: Belongs to the UPF0568 family. Database links: Entrez Gene: 51637 Human Entrez Gene: 68045 Mouse Omim: 610858 Human SwissProt: Q9Y224 Human SwissProt: Q9CQE8 Mouse Unigene: 534457 Human Unigene: 21932 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CGI—99是一种定位于细胞核、细胞质的244氨基酸蛋白，属于UPF0568家族。CGI -99在多种组织中表达，在心脏和骨骼肌中具有特别高的水平，起到与Ninein相互作用的同源二聚体的作用，并被认为调节Nyin的功能。CGI -99在脑肿瘤组织中过表达，提示其在肿瘤发生和转移中的作用。编码CGI -99的基因映射到人类14号染色体，该基因含有700个以上的基因，并包含人类基因组的近3.5%。第14号染色体编码了早老素1（PSEN1）基因，这是与阿尔茨海默病（AD）发展相关的三个关键基因之一。SerpIA1基因也位于14号染色体上，当有缺陷时，会导致遗传障碍？抗胰蛋白酶缺乏症，表现为严重的肺部并发症和肝功能不全。