FITC标记的磷酸化相似肿瘤抑制基因HUGL抗体
产品名称： FITC标记的磷酸化相似肿瘤抑制基因HUGL抗体
英文名称： Anti-phospho-LLGL1 + LLGL2(Ser650+Ser654)/FITC
产品编号： HZ-6070R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-phospho-LLGL1 + LLGL2(Ser650+Ser654)/FITC Conjugated antibody
FITC标记的磷酸化相似肿瘤抑制基因HUGL抗体
| 英文名称 | Anti-phospho-LLGL1 + LLGL2(Ser650+Ser654)/FITC |
| 中文名称 | FITC标记的磷酸化相似肿瘤抑制基因HUGL抗体 |
| 别 名 | LLGL1 + LLGL2 (phospho S650 + S654); LLGL1 + LLGL2 (phospho Ser650 + Ser654); p-LLGL1 + p-LLGL2 (S650 + S654); p-LLGL1/LLGL2 (Ser650 + Ser654); p-LLGL1/LLGL2 (S650 + S654); p-LLGL1/LLGL2 (Ser650/654); DLG4; HGL; HUGL; HUGL1; lethal giant larvae homolog 1; lethal giant larvae homolog 2; Lethal(2) giant larvae protein homolog 1; Lethal(2) giant larvae protein homolog 2; LGL2; LLGL; L2GL1_HUMAN; L2GL2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞周期蛋白 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, k |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 117kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthesised phosphopeptide derived from mouse LLGL1 around the phosphorylation site of Ser650+Ser654 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Function: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Subunit: Associated with nonmuscle myosin II heavy chain. Interacts with PRKCI/aPKC, PARD6B/Par-6 and PARD6A. Interacts with STX4A. Subcellular Location: Cytoplasm, cytoskeleton. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Tissue Specificity: Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated at least at Ser-663 by PRKCI. Similarity: Belongs to the WD repeat L(2)GL family. Contains 14 WD repeats. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
LLGL1是一种与Drosophila肿瘤抑制因子相似的蛋白。蛋白质是细胞骨架网络的一部分，与非肌肉肌球蛋白II重链和在丝氨酸残基上特异性磷酸化该蛋白的激酶有关。LLGL1基因位于17号染色体上的Smith-MaMeNIS综合征区域内。LLGL2是一种类似果蝇致死巨幼虫的蛋白质。在飞行中，蛋白质的定位细胞命运决定因子的能力是由非典型蛋白激酶C（APKC）调节的。在人类中，这种蛋白质与含有APKC的复合物相互作用，并在有丝分裂细胞中定位。