FITC标记的FGD4蛋白抗体
产品名称： FITC标记的FGD4蛋白抗体
英文名称： Anti-FGD4/FITC
产品编号： HZ-16080R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
上海沪震实业有限公司
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-FGD4/FITC Conjugated antibody
FITC标记的FGD4蛋白抗体
| 英文名称 | Anti-FGD4/FITC |
| 中文名称 | FITC标记的FGD4蛋白抗体 |
| 别 名 | 9030023J02Rik; 9330209B17Rik; Actin filament binding protein frabin; Actin filament-binding protein frabin; CMT4H; DKFZp313E1818; DKFZp434K1572; FGD1 related F actin binding protein; FGD1-related F-actin-binding protein; Fgd4; FGD4_HUMAN; FLJ34370; FLJ42663; FRABP; FYVE; FYVE, RhoGEF and PH domain containing 4; MGC57222; RhoGEF and PH domain-containing protein 4; ZFYVE6; Zinc finger FYVE domain containing protein 6; Zinc finger FYVE domain-containing protein 6. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 细胞骨架 G蛋白信号 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 87kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human FGD4 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. [provided by RefSeq, Oct 2008] Function: Activates CDC42, a member of the Ras-like family of Rho-and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8. Subcellular Location: Cytoplasm > cytoskeleton. Cell projection > filopodium. Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers. Tissue Specificity: Expressed in different tissues, including brain, cerebellum, peripheral nerve, skeletal muscle, heart, uterus, placenta and testis. Similarity: Contains 1 DH (DBL-homology) domain. Contains 1 FYVE-type zinc finger. Contains 2 PH domains. Database links: Entrez Gene: 121512 Human Omim: 611104 Human SwissProt: Q96M96 Human Unigene: 117835 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
该基因编码一种参与调节肌动蛋白细胞骨架和细胞形状的蛋白质。该蛋白含有肌动蛋白丝结合结构域，与它的dBL同源结构域及其pLekkistin同源结构域之一，可以形成微尖峰。该蛋白可以独立于肌动蛋白丝结合结构域激活MAPK8，并且通过结合的GDP交换游离GTP参与CDC42的激活。CDC42的激活也使得该蛋白在介导小隐孢子虫的细胞侵袭中发挥作用，小隐孢子虫是一种感染胃肠道的细胞内寄生虫。该基因的突变可引起玛丽氏牙病型4H（CMT4H），这是周围神经系统的一种障碍。[ RefSeq，OCT 2008提供]