FITC标记的锌指蛋白339抗体
产品名称： FITC标记的锌指蛋白339抗体
英文名称： Anti-OVOL2/FITC
产品编号： HZ-12274R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-OVOL2/FITC Conjugated antibody
FITC标记的锌指蛋白339抗体
| 英文名称 | Anti-OVOL2/FITC |
| 中文名称 | FITC标记的锌指蛋白339抗体 |
| 别 名 | bA504H3.3; EUROIMAGE566589; hOvo 2; hOvo2; Ovo like 2 (Drosophila); Ovo like 2; OVOL 2; Transcription factor Ovo like 2; Zinc finger protein 339; ZNF 339; ZNF339; OVOL2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 发育生物学 干细胞 转录调节因子 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Cow, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 30kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human OVOL2 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: The Ovo family of zinc-finger transcription factors encode evolutionarily conserved genes including those from Caenorhabditis elegans, Drosophila melanogaster, mouse and human. Members of the Ovo family include Ovol1 and Ovol2. Ovol1 acts as a transcriptional repressor by interacting with key developmental signaling pathways such as Wnt and TGF-∫/BMP. Specifically, Ovol1 represses c-Myc and Id2 genes and establishes a balance between proliferation and differentiation of progenitor cells. Deletion of Ovol1 in mice leads to germ cell degeneration and defective sperm production in adult males. Ovol1 has also been shown to repress itself as well as Ovol2, which is thought to regulate neural development and vascular angiogenesis during embryogenesis. Function: OVOL2 (Ovo like 2) contains 4 C2H2 type zinc fingers. It belongs to the krueppel C2H2 type zinc finger protein family. It is a DNA binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. It probably acts as a transcription regulator. Subcellular Location: Nuclear. Tissue Specificity: Expressed in testis, ovary, heart and skeletal muscle. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 4 C2H2-type zinc fingers. Database links: Entrez Gene: 58495 Human Entrez Gene: 107586 Mouse Entrez Gene: 296201 Rat SwissProt: Q9BRP0 Human SwissProt: Q8CIV7 Mouse Unigene: 661013 Human Unigene: 710157 Human Unigene: 252750 Mouse Unigene: 104639 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Ovo家族的锌指转录因子编码进化上保守的基因，包括来自秀丽隐杆线虫、果蝇、小鼠和人的基因。Ovo族的成员包括OVRO1和OVRO2。OVOL1通过与Wnt和TGF-β/BMP等关键的发育信号通路相互作用而发挥转录阻遏作用。特别地，Ovol1抑制c-Myc和Id2基因，并在祖细胞的增殖和分化之间建立平衡。OVAL1在小鼠中的缺失导致成年男性生殖细胞变性和有缺陷的精子产生。Ovol1还显示出抑制自身以及Ovol2，后者被认为在胚胎发生期间调节神经发育和血管新生。