FITC标记的跨膜丝氨酸蛋白酶3抗体
产品名称： FITC标记的跨膜丝氨酸蛋白酶3抗体
英文名称： Anti-TMPRSS3/FITC
产品编号： HZ-4478R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-TMPRSS3/FITC Conjugated antibody
FITC标记的跨膜丝氨酸蛋白酶3抗体
| 英文名称 | Anti-TMPRSS3/FITC |
| 中文名称 | FITC标记的跨膜丝氨酸蛋白酶3抗体 |
| 别 名 | Deafness autosomal recessive 10; DFNB10; DFNB8; ECHOS1; Gene similar to transmembrane serine protease; MGC130589; Serine protease TADG-12; si:dz69g10.3; TADG12; TMPRSS 3; TMPRSS3; TMPS3_HUMAN; Transmembrane protease serine 3; Tumor associated differentially expressed gene 12 protein; Tumor-associated differentially-expressed gene 12 protein; UNQ323/PRO382. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 神经生物学 跨膜蛋白 泛素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 49kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TMPRSS3 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012] Function: Probable serine protease that play a role in hearing. Acts as a permissive factor for cochlear hair cells survival and activation at the onset of hearing and is required for saccular hair cell survival (By similarity). Activates ENaC (in vitro). Subcellular Location: Endoplasmic reticulum membrane. Tissue Specificity: Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas. Post-translational modifications: Undergoes autoproteolytic activation. DISEASE: Defects in TMPRSS3 are the cause of deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in TMPRSS3 are the cause of deafness autosomal recessive type 10 (DFNB10) [MIM:605316]. Similarity: Belongs to the peptidase S1 family. Contains 1 LDL-receptor class A domain. Contains 1 peptidase S1 domain. Contains 1 SRCR domain. Database links: Entrez Gene: 64699 Human Entrez Gene: 140765 Mouse Omim: 605511 Human SwissProt: P57727 Human SwissProt: Q8K1T0 Mouse Unigene: 208600 Human Unigene: 214638 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
该基因编码属于丝氨酸蛋白酶家族的蛋白质。编码蛋白包含丝氨酸蛋白酶结构域、跨膜结构域、LDL受体样结构域和富含半胱氨酸的清道夫受体结构域。已知丝氨酸蛋白酶涉及多种生物过程，其功能失调常常导致人类疾病和疾病。该基因通过其与先天性和儿童期常染色体隐性耳聋的关联而被鉴定。该基因在胎儿耳蜗和许多其他组织中表达，被认为与内耳的发育和维持或外淋巴和内淋巴的内容物有关。该基因也被鉴定为在卵巢肿瘤中过度表达的肿瘤相关基因。另外，已经描述了剪接转录变体。[ RefSeq，2012月1日]