FITC标记的纺锤体组装异常蛋白6抗体
产品名称： FITC标记的纺锤体组装异常蛋白6抗体
英文名称： Anti-SASS6/FITC
产品编号： HZ-9301R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-SASS6/FITC Conjugated antibody
FITC标记的纺锤体组装异常蛋白6抗体
| 产品编号 | bs-9301R-FITC |
| 英文名称 | Anti-SASS6/FITC |
| 中文名称 | FITC标记的纺锤体组装异常蛋白6抗体 |
| 别 名 | HsSAS 6; HsSAS6; MGC119440; SAS 6; SAS6; SASS 6; Spindle assembly 6 homolog (C. elegans); Spindle assembly 6 homolog; Spindle assembly abnormal protein 6 homolog; PJA2_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 细胞周期蛋白 细胞分化 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 74kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SASS6 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole. Function: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Subunit: Binds ubiquitin-conjugating enzymes (E2s). In vitro, interacts with the ubiquitin-conjugating enzyme, UBE2D2. The phosphorylated form interacts with PRKAR1A, PRKAR2A and PRKAR2B. Binds the catalytic subunits of cAMP-dependent protein kinase. Subcellular Location: Cytoplasm. Cell membrane. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cell junction, synapse (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus. Expressed in the postsynaptic density region of synapses (By similarity). Co-localizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane. Similarity: Contains 1 RING-type zinc finger. Database links: Entrez Gene: 163786 Human Omim: 609321 Human SwissProt: Q6UVJ0 Human Unigene: 591447 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
SAS-6（纺锤体组装异常蛋白6同源物，HSSAS-6）是由人类基因SAS6编码的657氨基酸蛋白。SAS-6是包含一个PISA（存在于SAS-6）结构域的中心体的一个组成部分。LK4、SAS-6、CPAP和其他中心粒相关蛋白在前中心粒形成的不同阶段需要，并与不同的中心粒结构相关。SAS-6只与新生的中心粒短暂关联，而CEP135和CPAP在父母和初生中心粒的近侧管腔内形成核心结构。SAS-6对于人细胞系中的前中心粒形成是必要的，并且在中心粒形成开始时与中心粒不对称地定位。SAS-6水平在细胞周期中振荡，在分裂后期开始有丝分裂，在随后的G1期结束时再次积累。后期促进复合物以26S蛋白酶体降解SAS-6为目标，SAS-6 C端的KEN盒是降解的必要条件。SAS-6水平的增加促进了形成一个中心粒旁的多个前中心粒的形成。